PRSs have been applied and characterized within global populations, but there is limited understanding of PRS accuracy in recently admixed individuals and whether this varies with ancestry. Studies applying PRSs in diverse populations3, 4, 5,9 or exploring potential statistical approaches to improve accuracy in such populations6,10 typically present performance metrics averaged across all admixed individuals. Only one study to date has suggested that PRS accuracy may be a function of genetic admixture (i.e., for height in the UK Biobank8). However, it is unknown if the relationship between accuracy and ancestry exists when variants are discovered in non-European populations or what the best approach for applying PRSs to admixed individuals will be when there are adequately powered GWASs in non-European populations.
