gene-environment interactions.4 However, in traits such as BMI and type 2 diabetes, 70%–80% of European-based PRS accuracy loss in African ancestry has been attributed to differences in allele frequency and LD; therefore, most causal variants discovered in Europeans are likely to be shared.5 Recent methods developed to improve PRS accuracy in non-Europeans have prioritized the use of European-discovered variants and population-specific weighting.6, 7, 8 However, only small gains in accuracy are possible with limited sample sizes of non-European cohorts.4
