Third, we elicited perspectives from “informed investigators” who had published most extensively on or were the original or firmest proponents of a particular candidate gene in schizophrenia. These individuals were identified using PubMed searches: (gene [All Fields] OR “protein name” [All Fields]) AND (“schizophrenia” [MeSH Terms] OR “schizophrenia” [All Fields]). Informed investigators were contacted to request their summary judgment of the current status of one particular gene as a genetic risk factor for schizophrenia (1=very unlikely and 5=very likely). Genetic risk could refer to common, uncommon, rare, private, or de novo genetic variation. A draft of Table 2 was supplied upon request. Informed investigators were given the opportunity to include text in the Supplement to explain their rating.
