We evaluated these 25 historical candidate genes for schizophrenia in four ways. First, we conducted fixed-effects meta-analyses for all genetic markers in these 25 genes using summary data on subjects of European ancestry in the SZGene database. 2 Second, we included PGC results for schizophrenia (9.5 million markers in 34,241 cases, 45,604 controls, and 1,235 trios followed by replication analyses of 263 SNPs in 1,513 cases and 66,236 controls). 11 We report the results for the same SNP appearing in SZGene and for the SNP with the smallest P-value in a gene (± 25 kb).
