The second gene, CADM2, is a synaptic cell adhesion molecule (SynCAM family) belonging to the immunoglobulin (Ig) superfamily. Variants in the CADM2 gene have been previously associated with body mass index,56 processing speed57 and autism disorders.58 Interestingly, these phenotypes were associated with cannabis use in previous studies,59, 60, 61 which together suggest that CADM2 can be considered an important gene related to a variety of complex traits. It is possible that the association with lifetime cannabis use may be driven, for example, by differences in personality rather than as a direct relationship with lifetime use.
