All analyses were repeated with each individual expression-specific contrast. All reported effects were confirmed with respect to amygdala activity to fearful expressions using the Fear>Shapes contrast (Supplementary Figure 4–Supplementary Figure 6), but not for any of the other expressions (all p values > 0.17). Notably, in the model using the Fear>Shapes contrast, LESS predicted higher likelihood of being diagnosed with an AUD at less extreme values in the low amygdala-high VS phenotype (1 SD below and above the mean, respectively) in comparison to the model using the more general All Faces>Shapes contrast (Supplementary Figure 4d).
