In a subsample of participants who completed a follow-up survey (n=232, 136 women, mean age at follow up 19.64±1.22; b=−0.469, p=0.044), amygdala reactivity and VS activity further interacted to predict the relationship between LESS and AUDIT scores reported three months following completion of the DNS protocol including neuroimaging. This relationship remained trending when accounting for CTQ scores and demographic variables including age, gender, and race/ethnicity (b=−0.441, p=0.068; Figure 5). Importantly, LESS was associated with AUDIT scores primarily in participants with the low VS-high amygdala risk phenotype (p=0.021), while the effect was less reliable for those with the high VS-low amygdala risk phenotype (p=0.080).
