Genes implicated by mapping of significant GWAS SNPs were further investigated using the GENE2FUNC procedure in FUMA24, which provides hypergeometric tests of enrichment of the list of mapped genes in 53 GTEx48 tissue-specific gene expression sets, 7,246 MSigDB gene-sets52, and 2,195 GWAS catalog gene-sets28. The Bonferroni-corrected significance threshold was 0.05/9,494 gene-sets=5.27×10-6.
