Fig. 4A illustrates the results using the derived dichotomous total CTQ score and shows that the prevalence of suicide attempt in individuals exposed to high childhood trauma was 0.35 in carriers of only the FKBP5 rs3800373 major homozygote (cc/FF) and 0.30 in carriers of only the CRHBP rs7728378 major homozygote (CC/ff) however the prevalence increased to 0.58 in carriers of both major homozygotes (CC/FF). In contrast, individuals who were not carriers of either major homozygote (cc/ff) were resilient to the effects of childhood trauma; the prevalence of suicide attempt was the same in these individuals (0.24) as in all other genotype groups who had not experienced childhood trauma (0.16–0.22).
