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Chunk #29 — 3. Results — 3.2. Independent and additive effects of CRHBP and FKBP5 — 3.2.2. Additive effects

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Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior.
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An analysis of the interaction of total CTQ score (continuous variable) with combined FKBP5 rs3800373 and CRHBP rs7728378 genotypes for each individual was significant within the logistic regression model: L-R χ2 =11.6, 3 df, p = 0.0087. The interaction term contributed 2.4% of the variance within the total model. This represents the sum of the interaction term variance in the independent FKBP5 rs3800373 (1.4%) and CRHBP rs7728378 (1.2%) models.