[22] reported seeing differential gene expression as early as the NP stage between BPD and control population. This discrepancy might be due to their use of an enriched NP population (CXCR4+) or the different analytical platforms employed. RNA-seq has a wider dynamic range and is more sensitive than microarray which may also have contributed to the identification of DEGs at this time point. In their study of iPSC-derived neurons differentiated for 6 weeks, Madison et al. found 44 DEGs between BPD and controls using the 352 custom PsychGene Nanostring probe set. We saw no overlap between their DEGs and the DEGs that we identified between BPD and control samples in our L neuronal population.
