Child and adult psychopathology is sometimes broadly dichotomized into externalizing problems and disorders, involving characteristics such as impulsivity, sensation seeking, and aggression, and internalizing problems and disorders, involving characteristics such as anxiety and depression.1 The robust association between the externalizing domain and substance problems is well documented.2 For example, young adolescents with conduct disorder are at elevated risk to develop alcohol use disorders in adulthood,3 and the two diagnoses share some genetic4 and electrophysiological5,6 risk factors.
