From October 1997 through June 2010, 1,403 persons agreed to annual detailed clinical evaluation and donation of the brain, spinal cord, nerve, and muscle at the time of death. Of these, 1,372 completed their baseline clinical evaluation: 72.7% were women; 86.9% were white, non-Hispanic; their mean age was 80.0 years; and mean education was 14.3 years with 34.0% with 12 or fewer years of education. There were 250 cases of incident dementia and 238 cases of incident Alzheimer’s disease with or without a coexisting condition. Details of the clinical and pathologic methods have been previously reported 51. To avoid population stratification artifacts in the genetic analyses, the study was limited to non-Latino whites.
