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Chunk #13 — Background — SNPs, microsatellites, and association

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Construction of the model for the Genetic Analysis Workshop 14 simulated data: genotype-phenotype relationships, gene interaction, linkage, association, disequilibrium, and ascertainment effects for a complex phenotype.
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We also included the opportunity for participants to ask questions about microsatellite vs. SNP markers, to pursue "fine" mapping, and to detect association of the disease with SNPs. Because we included control data in the more detailed SNP data (which were not distributed to participants with the coarse SNP and microsatellite data but could be downloaded from the internet), participants had the option of doing family-based or case-control-based association analyses. We did not simulate population stratification.