There are a number of tools that offer similar functionality as GeneMANIA and that are available on the web or through Cytoscape. These tools include: STRING (9), N-browse (31), IMP (32), FunctionalNet (33) and FunCoup (34). Each system draws from slightly different data sources and makes different decisions about how to score interactions, and we encourage readers to also evaluate these systems. There are also systems that provide access to a set of pre-defined gene function predictions made on the basis of network and gene attribute data (35).