To increase homogeneity and evaluate population specific linkages, samples of European ancestry (or mostly European ancestry) were analyzed separately. Since the primary GSMA on MaxCigs24 only included European ancestry populations, secondary analysis by European ancestry only needed to be carried out for smoking behavior and FTND. Figures S1 and S2 in the Supplement illustrate the results across all bins for smoking behavior and FTND, respectively. Here, we report the results of the European ancestry GSMA compared with the overall GSMA in weighted analysis. Briefly, 11 genome scan results were included for analysis of smoking behavior (2486 families with 7270 subjects). Bin 17.4 still achieved suggestive linkage (PSR=0.002). Three bins (11.1, 3.8 and 5.4) were no longer significant and two bins (22.2 and 5.6) became nominally significant (Table 2). For the FTND phenotype, three genome scan results were included (625 families with 1878 subjects). Two bins (6.6 and 5.4) were no longer significant and 2 bins (5.7 and 5.6) became significant (Table 3).
