In order to identify weak linkage signals near the boundaries of two bins, we re-analyzed the data using a shifted 30cM bin GSMA starting at the midpoint of the bins used in the primary analysis. Figures S3, S4 and S5 in the Supplement illustrate the genomewide results using the shifted 30cM GSMA for smoking behavior, FTND and MaxCigs24, respectively. Here, we report the bins which achieved genomewide suggestive evidence for linkage (weighted analysis) in this secondary analysis. In the analysis of smoking behavior, bin 16.1 (16p13.2–16p12.1), achieved genomewide suggestive linkage in both all (PSR =0.0074) and European-ancestry (PSR=0.0085) samples. Bin 5.6 (5q33.1–5q35.2) reached genomewide suggestive linkage for FTND in European-ancestry samples (PSR=0.0076). In the analysis of the MaxCigs24 trait, bin 22.1 (22q11.22–22q13.2) reached genomewide suggestive linkage (PSR=0.0016).
