Familial risk for AD has also been shown to be associated with a reduction in right/left ratios of orbitofrontal volume (Hill et al., 2009), and reduction in volume of the hippocampus and the parahippocampal gyrus (Benegal et al., 2007; Sjoerds et al., 2013). The nucleus accumbens has also been reported to be influenced by the family density of alcoholism with positive associations seen in drug and alcohol naive female adolescent offspring from families with AD (Cservenka et al., 2015).
