The KCNJ6 gene encodes a potassium channel (GIRK2) with inhibitory effects on dopaminergic tone that is enhanced by CRH. Individuals (age 19) exposed to high family adversity and more severe recent SLEs (assessed separately, not cumulatively) who were also carriers of the minor homozygote (GG) of SNP rs2836016, previously associated with adulthood AD, had the highest AUDIT (Alcohol Use Disorders Identification Test) scores [69].
