Increased severity of adolescent SLEs was associated with earlier age at first drink and heavier alcohol consumption, but only in carriers of the CRHR1 rs1876831 CC major homozygote. Similar results were obtained at ages 15 and 19 years [70, 71]. Corresponding results were found in a group of more than 1,000 adults from the Nicotine Addiction Genetics project. In this sample, CSA was associated with greater lifetime alcohol consumption and AD only among adults homozygous for the haplotype (chromosomal region) that included the rs1876831 C allele [72].
