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Chunk #27 — Methods — Evaluation of PRS

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Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations.
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We obtained an overall OR for the African population at various cutoffs by meta-analyzing estimates from the eMERGE African dataset with estimates from the four UAB Black cohorts using an inverse-variance-weighted approach; we obtained an overall OR for the East Asian population at various cutoffs by meta-analyzing the three TWB batches.