rs4360494 associated with increased PP (0.278 mmHg ±0.03, P=3.7x10-16, N=307,682) is associated with SF3A3 expression in human VSMCs, although not in endothelial cells (Supplementary Fig. 13a); and the T allele of SNV rs62012628 in ADAMTS7 associated with lower DBP (0.238 mmHg ±0.03, P=5.1x10-12, N=244,143), is associated with reduced ADAMTS7 expression in human VSMCs (Supplementary Fig. 13b), while the minor A allele of SNV rs2289125 at the NOX4 locus associated with lower PP (-0.377 mmHg ±0.04, P=9.1x10-22, N=282,851) correlates with increased NOX4 expression in ECs though not VSMCs (Supplementary Fig. 13c). Our study thus finds evidence for novel cis-eQTLs in ADAMTS7 and NOX4 in addition to validating the previously reported GTEx eQTL in SF3A3, and supports the vascular expression of these genes.
