Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
paper
Cited
Public
- Authors
- Warren, Helen R; Evangelou, Evangelos; Cabrera, Claudia P; Gao, He; Ren, Meixia; Mifsud, Borbala; Ntalla, Ioanna; Surendran, Praveen; Liu, Chunyu; Cook, James P; Kraja, Aldi T; Drenos, Fotios; Loh, Marie; Verweij, Niek; Marten, Jonathan; Karaman, Ibrahim; Lepe, Marcelo P Segura; O'Reilly, Paul F; Knight, Joanne; Snieder, Harold; Kato, Norihiro; He, Jiang; Tai, E Shyong; Said, M Abdullah; Porteous, David; Alver, Maris; Poulter, Neil; Farrall, Martin; Gansevoort, Ron T; Padmanabhan, Sandosh; MΓ€gi, Reedik; Stanton, Alice; Connell, John; Bakker, Stephan J L; Metspalu, Andres; Shields, Denis C; Thom, Simon; Brown, Morris; Sever, Peter; Esko, TΓ΅nu; Hayward, Caroline; van der Harst, Pim; Saleheen, Danish; Chowdhury, Rajiv; Chambers, John C; Chasman, Daniel I; Chakravarti, Aravinda; Newton-Cheh, Christopher; Lindgren, Cecilia M; Levy, Daniel; Kooner, Jaspal S; Keavney, Bernard; Tomaszewski, Maciej; Samani, Nilesh J; Howson, Joanna M M; Tobin, Martin D; Munroe, Patricia B; Ehret, Georg B; Wain, Louise V; International Consortium of Blood Pressure (ICBP) 1000G Analyses; BIOS Consortium; Lifelines Cohort Study; Understanding Society Scientific group; CHD Exome+ Consortium; ExomeBP Consortium; T2D-GENES Consortium; GoT2DGenes Consortium; Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium; International Genomics of Blood Pressure (iGEN-BP) Consortium; UK Biobank CardioMetabolic Consortium BP working group
- Year
- 2017
- Journal
- Nature genetics
- PMID
- 28135244
- DOI
- 10.1038/ng.3768
- PMCID
- PMC5972004
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.
Study design schematic for discovery and validation of loci. N: sample size; QC: Quality Control; PCA: Principal Component Analysis; BP: blood pressure; SBP: systolic BP; DBP: diastolic BP; PP: pulse pressure; SNVs: single nucleotide variants; BMI: body mass index; UKB: UK Biobank; UKBL: UK BiLEVE; GWAS: Genome-wide association study; MAF: Minor Allele Frequency; P: P-value; LD: Linkage Disequilibrium; 1000G: 1000 Genomes. UKBBvsUKBL: a binary indicator variable for UK Biobank vs UK BiLEVE to adjust for the different genotyping chips
Venn diagram of 107 validated loci from our study. This shows concordance of significant associations across the three blood pressure phenotypes for the 107 validated sentinel variants (Tables 1-3) from both the GWAS and exome analyses, according to genome-wide significance in the combined meta-analysis. The locus names labelled within the Venn Diagram correspond to Tables 1-3, and relate to the nearest annotated gene. The loci names in bold font highlight the 32 novel loci which are reported for the first time in our study.
Distribution of Genetic Risk Score (GRS) and its relationship with blood pressure, hypertension and CVD outcomes. The GRS is based on all reported loci: both previously reported loci at the time of analysis; and all validated blood pressure variants from this study. (a) Distribution of GRS in Airwave and sex-adjusted odds ratio of hypertension in age 50+ comparing each of the upper four GRS quintiles with the lowest quintile; dotted lines represent the upper 95% confidence intervals. (b) Mean blood pressures and standard deviation in bracket in Airwave age 50+ across GRS quintiles. (c) Distribution of GRS in UKB and sex-adjusted odds ratio of CVD, CAD and stroke comparing each of the upper four GRS quintiles with the lowest quintile; dotted lines represent the upper 95% confidence intervals. (d) Count of CVD, CAD and stroke (events and deaths) across GRS quintiles in UKB participants
Summary of gene cardiovascular expression from validated loci. Genes are shown on the basis of their tissue expression and supporting evidence summarised in Supplementary Table 16, based on Knockout (KO) phenotype, previously reported blood pressure biology or a strong functional rationale: eQTL (expression Quantitative Trait Loci), nsSNV (non-synonymous SNV), Hi-C. Multiple lines of evidence indicate the central importance of the vasculature in blood pressure regulation and we thus highlight existing drugged (*) and druggable (#) targets among these genes. Illustrations used elements with permission from Servier Medical Art. We note that some druggable genes may carry a safety liability, such as GJA1, which has known association with QT interval20
1β20 of 66
Next β
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| 2026 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association. | Palaniappan LP et al. | β | 2026 | β |
| Accelerated epigenetic age in hypertension: a systematic review and meta-analysis. | Dollin C et al. | β | 2026 | β |
| Combining xQTL and genome-wide association studies from diverse populations improves druggable gene discovery. | Lorincz-Comi N et al. | β | 2026 | β |
| Partitioned polygenic scores show mechanistic heterogeneity in type 2 diabetes and hypertension comorbidity. | Pascat V et al. | β | 2026 | β |
| Pharmacogenomic insights into angiotensin converting enzyme inhibitors and calcium channel blockers for personalized hypertension treatment. | Banji D et al. | β | 2026 | β |
| The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025). | Ohya Y et al. | β | 2026 | β |
| 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association. | Martin SS et al. | β | 2025 | β |
| A Narrative Review of the Genetic Architecture of Systemic Hypertension: From Candidate Genes to Biobank-Scale Genome-Wide Association Studies and Sequencing, With Translational Pathways to Precision Care. | Aldhufairi A et al. | β | 2025 | β |
| Appraisal of multiple polygenic risk scores to estimate the risk of myocardial infarction and coronary artery lesions. | Manikpurage HD et al. | β | 2025 | β |
| Blood DNA Methylation Analysis Reveals a Distinctive Epigenetic Signature of Vasospasm in Aneurysmal Subarachnoid Hemorrhage. | FernΓ‘ndez-PΓ©rez I et al. | β | 2025 | β |
| CCDC141 is a Connectin/Titin and Nesprin-1 binding protein that adapts cardiomyocytes to mechanical stress. | Hanashima A et al. | β | 2025 | β |
| Circulating mediators linking cardiometabolic diseases to HFpEF: a mediation Mendelian randomization analysis. | Lin M et al. | β | 2025 | β |
| Dementia risk across distinct metabolic profiles in the UK Biobank. | Lumsden AL et al. | β | 2025 | β |
| Development and Validation of Polygenic Risk Scores for Blood Pressure Traits in Continental African Populations. | Onyenobi E et al. | β | 2025 | β |
| Differential Transcription Factor Activator Protein-2 Delta Genotypes Affect the Levels of Interleukin-1 Beta, Interleukin 8, and Vascular Endothelial Growth Factor-C in the Retinal Pigment Epithelial Cells after Long-term Light Exposure. | Chin CH et al. | β | 2025 | β |
| Different Polymorphisms of the Renin-Angiotensin-Aldosterone System Genes are Associated with Poorer Blood Pressure Control in Hypertensive Older Adults. | Freire IV et al. | β | 2025 | β |
| Distinct pathway-based effects of blood pressure and body mass index on cardiovascular traits: comparison of novel Mendelian randomization approaches. | Leyden GM et al. | β | 2025 | β |
| Effects of Plasma Aldosterone and Renin Concentrations With Blood Pressure Variation and Hypertension Risk in Chinese Adults: A Population-Based Hakka Biobank Study. | Fang F et al. | β | 2025 | β |
| Epigenomic landscape of single vascular cells reflects developmental origin and disease risk loci. | Weldy CS et al. | β | 2025 | β |
| Genetic polymorphisms influencing antihypertensive drug responses. | El Cheikh J et al. | β | 2025 | β |
| Genetic Risk for Hypertension Increases the Effect of Salt Intake on the Risk of Incident CKD. | Heo GY et al. | β | 2025 | β |
| Genetics of Hypertension: Additive and Interactive Effects. | Pausova Z et al. | β | 2025 | β |
| Genome-wide association study provides novel insight into the genetic architecture of severe obesity. | Krishnan M et al. | β | 2025 | β |
| Harnessing the power of genomics in hypertension: tip of the iceberg? | Naderi H et al. | β | 2025 | β |
| Identity-by-descent mapping using multi-individual IBD with genome-wide multiple testing adjustment | Cai R et al. | β | 2025 | β |
| Identity-By-Descent Mapping Using Multi-Individual IBD With Genome-Wide Multiple Testing Adjustment. | Cai R et al. | β | 2025 | β |
| Impact of perinatal hypertonic NaCl access on adult offspring's sodium intake and angiotensin and vasopressin systems under hypertension model. | Porcari CY et al. | β | 2025 | β |
| Integrating genetics, metabolites, and clinical characteristics in predicting cardiometabolic health outcomes using machine learning algorithms - A systematic review. | Zhu X et al. | β | 2025 | β |
| MR-link-2: pleiotropy robust cis Mendelian randomization validated in three independent reference datasets of causality. | van der Graaf A et al. | β | 2025 | β |
| Multiple system biology approaches reveals the role of the hsa-miR-21 in increasing risk of neurological disorders in patients suffering from hypertension. | Mishra S et al. | β | 2025 | β |
| Prospective associations of genetic susceptibility to high blood pressure and muscle strength with incident cardiovascular disease outcomes. | Wang M et al. | β | 2025 | β |
| Sex-Biased Admixture Followed by Isolation and Adaptive Evolution Shaped the Genomic and Blood Pressure Diversity of the LopNur People. | Wen J et al. | β | 2025 | β |
| Structural and molecular dysfunctions in granulosa cells: A key contributor to porcine follicular atresia. | Guo Y et al. | β | 2025 | β |
| 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association. | Martin SS et al. | β | 2024 | β |
| Advancements of Biomacromolecular Hydrogel Applications in Food Nutrition and Health. | Ye Z et al. | β | 2024 | β |
| Aging reveals a sex-dependent susceptibility of sarcospan-deficient mice to cardiometabolic disease. | Rahimi Kahmini A et al. | β | 2024 | β |
| A new test for trait mean and variance detects unreported loci for blood-pressure variation. | Breeyear JH et al. | β | 2024 | β |
| APOE Ξ΅4 carriage associates with improved myocardial performance from adolescence to older age. | Topriceanu CC et al. | β | 2024 | β |
| A scalable and robust variance components method reveals insights into the architecture of gene-environment interactions underlying complex traits. | Pazokitoroudi A et al. | β | 2024 | β |
| Association analysis between an epigenetic alcohol risk score and blood pressure. | Bui H et al. | β | 2024 | β |
| Associations of combined genetic and lifestyle risks with hypertension and home hypertension. | Takase M et al. | β | 2024 | β |
| Causal role of immune cells in hypertension: a bidirectional Mendelian randomization study. | Zhang X et al. | β | 2024 | β |
| Concurrent exercise training potentiates the effects of angiotensin-converting enzyme inhibitor on regulatory systems of blood pressure control in ovariectomized hypertensive rats. | Ferreira MJ et al. | β | 2024 | β |
| Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate. | Mack TM et al. | β | 2024 | β |
| Genetically determined blood pressure, antihypertensive drug classes, and frailty: A Mendelian randomization study. | Zhuang Z et al. | β | 2024 | β |
| Genetic basis of right and left ventricular heart shape. | Burns R et al. | β | 2024 | β |
| Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets. | Xu X et al. | β | 2024 | β |
| Genetics of Hypertension: From Monogenic Analysis to GETomics. | Zappa M et al. | β | 2024 | β |
| Genetic Variants of Adrenoceptors. | Ahles A et al. | β | 2024 | β |
| Genetic variation in CCDC93 is associated with elevated central systolic blood pressure, impaired arterial relaxation, and mitochondrial dysfunction. | Kumar N et al. | β | 2024 | β |
| Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits. | Keaton JM et al. | β | 2024 | β |
| Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure. | Guirette M et al. | β | 2024 | β |
| Identification of novel proteins for coronary artery disease by integrating GWAS data and human plasma proteomes. | Li J et al. | β | 2024 | β |
| Integrated Single-Cell Transcriptomic Atlas of Human Kidney Endothelial Cells. | Zhang K et al. | β | 2024 | β |
| Metabolic Rewiring and Communication: An Integrative View of Kidney Proximal Tubule Function. | Chrysopoulou M et al. | β | 2024 | β |
| Polygenic risk scores associate with blood pressure traits across the lifespan. | Γvretveit K et al. | β | 2024 | β |
| Predictors of the Development of Associated Clinical Conditions in Working-Age Patients With Cardiovascular Risk Factors in Conditions of High Adherence to Treatment. | Koziolova NA et al. | β | 2024 | β |
| Prevalence of apical periodontitis and non-retention of root-filled teeth in hypertensive patients: Systematic review and meta-analysis. | Cabanillas-Balsera D et al. | β | 2024 | β |
| Proteome- and Transcriptome-Wide Genetic Analysis Identifies Biological Pathways and Candidate Drug Targets for Preeclampsia. | Ardissino M et al. | β | 2024 | β |
| SUMMIT-FA: a new resource for improved transcriptome imputation using functional annotations. | Melton HJ et al. | β | 2024 | β |
| The extracellular matrix protein fibronectin promotes metanephric kidney development. | Skoczynski K et al. | β | 2024 | β |
| The Genetic Variants Influencing Hypertension Prevalence Based on the Risk of Insulin Resistance as Assessed Using the Metabolic Score for Insulin Resistance (METS-IR). | Shine BK et al. | β | 2024 | β |
| The Inclusion of Underrepresented Populations in Cardiovascular Genetics and Epidemiology. | Chappell E et al. | β | 2024 | β |
| The Role of Diet in the Prevention of Hypertension and Management of Blood Pressure: An Umbrella Review of Meta-Analyses of Interventional and Observational Studies. | Aljuraiban GS et al. | β | 2024 | β |
| Update in genetic and epigenetic causes of hypertension. | Mani A | β | 2024 | β |
| Use of Genomics to Develop Novel Therapeutics and Personalize Hypertension Therapy. | Magavern EF et al. | β | 2024 | β |
| Using Machine Learning to Evaluate the Value of Genetic Liabilities in the Classification of Hypertension within the UK Biobank. | MacCarthy G et al. | β | 2024 | β |
| Utility of a Systolic Blood Pressure Polygenic Risk Score With Chlorthalidone Response. | Armstrong ND et al. | β | 2024 | β |
| Accounting for antihypertensive medication in Mendelian randomization studies of blood pressure: methodological considerations in the Canadian Longitudinal Study on Aging. | Mbutiwi FIN et al. | β | 2023 | β |
| A genome-wide by PM<sub>10</sub> exposure interaction study for blood pressure in Korean adults. | Kim HJ et al. | β | 2023 | β |
| A Genomic Risk Score Identifies Individuals at High Risk for Intracerebral Hemorrhage. | Myserlis EP et al. | β | 2023 | β |
| An individualized Bayesian method for estimating genomic variants of hypertension. | Rahman MA et al. | β | 2023 | β |
| Association between systolic blood pressure and low-density lipoprotein cholesterol with coronary heart disease according to age. | Wang N et al. | β | 2023 | β |
| Association of genetically-predicted placental gene expression with adult blood pressure traits. | Hellwege JN et al. | β | 2023 | β |
| Associations of polygenic risk scores for preeclampsia and blood pressure with hypertensive disorders of pregnancy. | Nurkkala J et al. | β | 2023 | β |
| Biallelic <i>NPR1</i> loss of function variants are responsible for neonatal systemic hypertension. | Capri Y et al. | β | 2023 | β |
| Biomarker and genomic analyses reveal molecular signatures of non-cardioembolic ischemic stroke. | Ding L et al. | β | 2023 | β |
| Blood pressure, calcium channel blockers, and the risk of prostate cancer: a Mendelian randomization study. | Kazmi N et al. | β | 2023 | β |
| Causal effect of beta-blockers on the risk of lung cancer: a Mendelian randomization study. | Lu Y et al. | β | 2023 | β |
| Combating hypertension beyond genome-wide association studies: Microbiome and artificial intelligence as opportunities for precision medicine. | Aryal S et al. | β | 2023 | β |
| Combination of genetic and environmental factors for childhood hypertension: a simple indicator of family history remains useful. | Metoki H et al. | β | 2023 | β |
| Combined handgrip strength and walking pace, genetic susceptibility, and incident hypertension: A prospective study in UK Biobank. | He P et al. | β | 2023 | β |
| Common and rare variant associations with latent traits underlying depression, bipolar disorder, and schizophrenia. | Dattani S et al. | β | 2023 | β |
| Cord Blood Insulin Concentration and Hypertension Among Children and Adolescents Enrolled in a US Racially Diverse Birth Cohort. | Wang G et al. | β | 2023 | β |
| Current State and Future of Polygenic Risk Scores in Cardiometabolic Disease: A Scoping Review. | Phulka JS et al. | β | 2023 | β |
| Decoding the mechanism of hypertension through multiomics profiling. | Adua E | β | 2023 | β |
| Development of a Systems Medicine Approach to Spinal Cord Injury. | Guest JD et al. | β | 2023 | β |
| Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI. | Yang Y et al. | β | 2023 | β |
| Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups. | Kurniansyah N et al. | β | 2023 | β |
| Fok I and Bsm I gene polymorphism of vitamin D receptor and essential hypertension: a mechanistic link. | Awasthi R et al. | β | 2023 | β |
| Gene-based association study reveals a distinct female genetic signal in primary hypertension. | Zucker R et al. | β | 2023 | β |
| Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure. | Siedlinski M et al. | β | 2023 | β |
| Genetic background influences arterial vasomotor function in male and female mice. | Holly D et al. | β | 2023 | β |
| Genetic Markers Regulating Blood Pressure in Extreme Discordant Sib Pairs. | Yasmin et al. | β | 2023 | β |
| Genetic Variants Associated With Systolic Blood Pressure in Children and Adolescents. | Pike MM et al. | β | 2023 | β |
| Genome-wide Association Studies of Retinal Vessel Tortuosity Identify Numerous Novel Loci Revealing Genes and Pathways Associated With Ocular and Cardiometabolic Diseases. | Tomasoni M et al. | β | 2023 | β |
| Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study. | Singh S et al. | β | 2023 | β |
| Genome-wide census of ATF4 binding sites and functional profiling of trait-associated genetic variants overlapping ATF4 binding motifs. | Γrd T et al. | β | 2023 | β |
| Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association. | Tsao CW et al. | β | 2023 | β |
| <i>LSS</i> rs2254524 Increases the Risk of Hypertension in Children and Adolescents with Obesity. | Umano GR et al. | β | 2023 | β |
| Integration of genetic fine-mapping and multi-omics data reveals candidate effector genes for hypertension. | van Duijvenboden S et al. | β | 2023 | β |
| Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response. | Dekkers KF et al. | β | 2023 | β |
| Meta-Analysis and Multivariate GWAS Analyses in 80,950 Individuals of African Ancestry Identify Novel Variants Associated with Blood Pressure Traits. | Udosen B et al. | β | 2023 | β |
| Metabolic Syndrome: An Overview on Its Genetic Associations and Gene-Diet Interactions. | Prone-Olazabal D et al. | β | 2023 | β |
| Mexican Biobank advances population and medical genomics of diverse ancestries. | Sohail M et al. | β | 2023 | β |
| New Insights into Polygenic Score-Lifestyle Interactions for Cardiometabolic Risk Factors from Genome-Wide Interaction Analyses. | D'Urso S et al. | β | 2023 | β |
| Phenotypic but not genetically predicted heart rate variability associated with all-cause mortality. | Tegegne BS et al. | β | 2023 | β |
| Polygenic risk scores for the prediction of cardiometabolic disease. | O'Sullivan JW et al. | β | 2023 | β |
| Polygenic Susceptibility to Hypertension and Cognitive Performance in Middle-aged Persons Without Stroke or Dementia. | Rivier CA et al. | β | 2023 | β |
| Poor sleep and shift work associate with increased blood pressure and inflammation in UK Biobank participants. | Kanki M et al. | β | 2023 | β |
| Prevalence and Awareness of Hypertension among a Rural Jazan Population. | Alhazmi L et al. | β | 2023 | β |
| Role of non-coding variants in cardiovascular disease. | Heshmatzad K et al. | β | 2023 | β |
| Source apportionment of heavy metals in PM<sub>2.5</sub> samples and effects of heavy metals on hypertension among schoolchildren in Tianjin. | Zhang J et al. | β | 2023 | β |
| Systematic characterization of regulatory variants of blood pressure genes. | Oliveros W et al. | β | 2023 | β |
| Telomere Length Associations With Clinical Diagnosis, Age, and Polygenic Risk Scores for Anxiety Disorder, Depression, and Bipolar Disorder. | Mutz J et al. | β | 2023 | β |
| Testing for association between exonic glucagon-like peptide 1 receptor mutation with physical and brain health traits in UK Biobank. | Ward J et al. | β | 2023 | β |
| The cysteine-altering p.R544C variant in the NOTCH3 gene is a probable candidate for blood pressure and relevant traits in the Taiwan Biobank. | Lin E et al. | β | 2023 | β |
| Type 2 Diabetes Modifies the Association of CAD Genomic Risk Variants With Subclinical Atherosclerosis. | Hasbani NR et al. | β | 2023 | β |
| What causes concordance of hypertension between spouses in India? Identifying a critical knowledge gap from a nationally representative cross-sectional sample of 63,020 couples aged 15β+βyears. | Nayak G et al. | β | 2023 | β |
| Whole-Exome Sequencing in Family Trios Reveals De Novo Mutations Associated with Type 1 Diabetes Mellitus. | Mousa M et al. | β | 2023 | β |
| [2022 Practice guidelines for the management of arterial hypertension of the Spanish Society of Hypertension]. | Gorostidi M et al. | β | 2022 | β |
| A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood. | Kurniansyah N et al. | β | 2022 | β |
| A new era in functional genomics screens. | Przybyla L et al. | β | 2022 | β |
| Assessing agreement between different polygenic risk scores in the UK Biobank. | Clifton L et al. | β | 2022 | β |
| Assessing the impact of blood pressure in the development of inflammatory bowel disease. | Xu X et al. | β | 2022 | β |
| Association Between Genetic Risk, Adherence to Healthy Lifestyle Behavior, and Thyroid Cancer Risk. | Feng X et al. | β | 2022 | β |
| Associations of Genome-Wide Polygenic Risk Score and Risk Factors With Hypertension in a Japanese Population. | Fujii R et al. | β | 2022 | β |
| Associations of maternal blood pressure-raising polygenic risk scores with fetal weight. | Workalemahu T et al. | β | 2022 | β |
| Clinical utility of polygenic risk scores for coronary artery disease. | Klarin D et al. | β | 2022 | β |
| Common Polymorphism That Protects From Cardiovascular Disease Increases Fibronectin Processing and Secretion. | Soubeyrand S et al. | β | 2022 | β |
| Depression with atypical neurovegetative symptoms shares genetic predisposition with immuno-metabolic traits and alcohol consumption. | Badini I et al. | β | 2022 | β |
| Disentangling Signatures of Selection Before and After European Colonization in Latin Americans. | Mendoza-Revilla J et al. | β | 2022 | β |
| Dissecting the Polygenic Basis of Primary Hypertension: Identification of Key Pathway-Specific Components. | Maj C et al. | β | 2022 | β |
| First genome-wide association study investigating blood pressure and renal traits in domestic cats. | Jepson RE et al. | β | 2022 | β |
| Gene-lifestyle interactions in the genomics of human complex traits. | Laville V et al. | β | 2022 | β |
| Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease. | Khera AV et al. | β | 2022 | β |
| Genetic analyses of circulating PUFA-derived mediators identifies heritable dihydroxyeicosatrienoic acid species. | McGurk KA et al. | β | 2022 | β |
| Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study. | Portilla-Fernandez E et al. | β | 2022 | β |
| Genetic architecture of heart failure with preserved versus reduced ejection fraction. | Joseph J et al. | β | 2022 | β |
| Genome-Wide Association Study on Carotid Intima-Media Thickness Identified New Risk Loci That Shares Genetic Risk With Cardiovascular Diseases. | Tcheandjieu C | β | 2022 | β |
| Genome-wide pleiotropy analysis identifies novel blood pressure variants and improves its polygenic risk scores. | Zhu X et al. | β | 2022 | β |
| GWAS of longitudinal trajectories at biobank scale. | Ko S et al. | β | 2022 | β |
| Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association. | Tsao CW et al. | β | 2022 | β |
| High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study. | Plotnikov D et al. | β | 2022 | β |
| High heritability of ascending aortic diameter and trans-ancestry prediction of thoracic aortic disease. | Tcheandjieu C et al. | β | 2022 | β |
| Identification of genetic loci simultaneously associated with multiple cardiometabolic traits. | Wood AC et al. | β | 2022 | β |
| Identifying pleiotropic genes for complex phenotypes with summary statistics from a perspective of composite null hypothesis testing. | Wang T et al. | β | 2022 | β |
| Identifying susceptibility genes for essential hypertension by transcriptome-wide association study. | Huang LJ et al. | β | 2022 | β |
| Impact of Dietary Fructose and High Salt Diet: Are Preclinical Studies Relevant to Asian Societies? | Khor BH et al. | β | 2022 | β |
| Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension. | Kelly TN et al. | β | 2022 | β |
| Investigating a Potential Causal Relationship Between Maternal Blood Pressure During Pregnancy and Future Offspring Cardiometabolic Health. | Wang G et al. | β | 2022 | β |
| Kidney omics in hypertension: from statistical associations to biological mechanisms and clinical applications. | Tomaszewski M et al. | β | 2022 | β |
| Large-Scale Multi-Omics Studies Provide New Insights into Blood Pressure Regulation. | Kamali Z et al. | β | 2022 | β |
| Low untreated systolic blood pressure over 18 years is associated with survival free of dementia age 90. | Kuller LH et al. | β | 2022 | β |
| Machine learning integration of multimodal data identifies key features of blood pressure regulation. | Louca P et al. | β | 2022 | β |
| Mendelian randomization and pathway analysis demonstrate shared genetic associations between lupus and coronary artery disease. | Kain J et al. | β | 2022 | β |
| Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk. | Zhou A et al. | β | 2022 | β |
| Personalizing treatments for patients based on cardiovascular phenotyping. | Leopold JA | β | 2022 | β |
| Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data. | Zhang MJ et al. | β | 2022 | β |
| Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors. | RamΓrez J et al. | β | 2022 | β |
| Prediction of incident atherosclerotic cardiovascular disease with polygenic risk of metabolic disease: Analysis of 3 prospective cohort studies in Korea. | Song H et al. | β | 2022 | β |
| Quantifying bias in psychological and physical health in the UK Biobank imaging sub-sample. | Lyall DM et al. | β | 2022 | β |
| Rare and common genetic determinants of metabolic individuality and their effects on human health. | Surendran P et al. | β | 2022 | β |
| Targeting the ASMase/S1P pathway protects from sortilin-evoked vascular damage in hypertension. | Di Pietro P et al. | β | 2022 | β |
| The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins Ξ±9Ξ²1 and Ξ±4Ξ²1. | Morris GE et al. | β | 2022 | β |
| Twenty-Five Novel Loci for Carotid Intima-Media Thickness: A Genome-Wide Association Study in >45β000 Individuals and Meta-Analysis of >100β000 Individuals. | Yeung MW et al. | β | 2022 | β |
| Understanding Factors That Cause Tinnitus: A Mendelian Randomization Study in the UK Biobank. | Cresswell M et al. | β | 2022 | β |
| Advances in Genomics Research of Blood Pressure Responses to Dietary Sodium and Potassium Intakes. | Razavi MA et al. | β | 2021 | β |
| An Academic Clinician's Road Map to Hypertension Genomics: Recent Advances and Future Directions MMXX. | Magavern EF et al. | β | 2021 | β |
| ANKRD36 Is Involved in Hypertension by Altering Expression of ENaC Genes. | Yan Y et al. | β | 2021 | β |
| A powerful subset-based method identifies gene set associations and improves interpretation in UK Biobank. | Dutta D et al. | β | 2021 | β |
| Arterial hypertension. | Brouwers S et al. | β | 2021 | β |
| Arterial Hypertension: Individual Therapeutic Approaches-From DNA Sequencing to Gender Differentiation and New Therapeutic Targets. | Luca CT et al. | β | 2021 | β |
| Association between polymorphism at IGF-1 rs35767 gene locus and long-term decline in renal function: a Japanese retrospective longitudinal cohort study. | Honda K et al. | β | 2021 | β |
| Association of Blood Pressure Genetic Risk Score with Cardiovascular Disease and CKD Progression: Findings from the CRIC Study. | Nierenberg JL et al. | β | 2021 | β |
| Bayesian variable selection with a pleiotropic loss function in Mendelian randomization. | Gkatzionis A et al. | β | 2021 | β |
| Causal Effect of Blood Pressure on Bone Mineral Density and Fracture: A Mendelian Randomization Study. | He B et al. | β | 2021 | β |
| Development of a risk prediction model for incident hypertension in Japanese individuals: the Hisayama Study. | Oishi E et al. | β | 2021 | β |
| Diet-gene interaction: effects of polymorphisms in the ACE, AGT and BDKRB2 genes and the consumption of sodium, potassium, calcium, and magnesium on blood pressure of normotensive adult individuals. | Giovanella J et al. | β | 2021 | β |
| Elevated Blood Pressure Increases Pneumonia Risk: Epidemiological Association and Mendelian Randomization in the UK Biobank. | Zekavat SM et al. | β | 2021 | β |
| Enhancers in disease: molecular basis and emerging treatment strategies. | Claringbould A et al. | β | 2021 | β |
| Examining Individual and Synergistic Contributions of PTSD and Genetics to Blood Pressure: A Trans-Ethnic Meta-Analysis. | Sumner JA et al. | β | 2021 | β |
| Fetal Undernutrition Programming, Sympathetic Nerve Activity, and Arterial Hypertension Development. | Mariano VS et al. | β | 2021 | β |
| From Precision Metapharmacology to Patient Empowerment: Delivery of Self-Care Practices for Epilepsy, Pain, Depression and Cancer Using Digital Health Technologies. | Bulaj G et al. | β | 2021 | β |
| Genetically Increased Telomere Length and Aging-Related Traits in the U.K. Biobank. | Demanelis K et al. | β | 2021 | β |
| Genetic approaches toward understanding the individual variation in cardiac structure, function and responses to exercise training. | Kim M et al. | β | 2021 | β |
| Genome-wide association study on blood pressure traits in the Iranian population suggests ZBED9 as a new locus for hypertension. | Kolifarhood G et al. | β | 2021 | β |
| Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities. | Huang LO et al. | β | 2021 | β |
| Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders. | van Duijvenboden S et al. | β | 2021 | β |
| Healthy Sleep Associated With Lower Risk of Hypertension Regardless of Genetic Risk: A Population-Based Cohort Study. | Li ZH et al. | β | 2021 | β |
| Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association. | Virani SS et al. | β | 2021 | β |
| Heritability Enrichment of Immunoglobulin G N-Glycosylation in Specific Tissues. | Li X et al. | β | 2021 | β |
| Meta-analysis of epigenome-wide association studies of carotid intima-media thickness. | Portilla-FernΓ‘ndez E et al. | β | 2021 | β |
| Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure. | Wang H et al. | β | 2021 | β |
| Multi-Omic Approaches to Identify Genetic Factors in Metabolic Syndrome. | Clark KC et al. | β | 2021 | β |
| Neuropeptide Y gene variants in obesity, dietary intake, blood pressure, lipid and glucose metabolism: A longitudinal birth cohort study. | Katus U et al. | β | 2021 | β |
| No Evidence for Passive Gene-Environment Correlation or the Influence of Genetic Risk for Psychiatric Disorders on Adult Body Composition via the Adoption Design. | Hunjan AK et al. | β | 2021 | β |
| One size does not fit all. Genomics differentiates among anorexia nervosa, bulimia nervosa, and binge-eating disorder. | HΓΌbel C et al. | β | 2021 | β |
| Placenta mediates the effect of maternal hypertension polygenic score on offspring birth weight: a study of birth cohort with fetal growth velocity data. | Sato N et al. | β | 2021 | β |
| Polygenic Risk Scores Predict Hypertension Onset and Cardiovascular Risk. | Vaura F et al. | β | 2021 | β |
| Precision Medicine Approaches to Vascular Disease: JACC Focus Seminar 2/5. | Miller CL et al. | β | 2021 | β |
| Risk Prediction Using Polygenic Risk Scores for Prevention of Stroke and Other Cardiovascular Diseases. | Abraham G et al. | β | 2021 | β |
| Single-cell analysis of salt-induced hypertensive mouse aortae reveals cellular heterogeneity and state changes. | Zhang K et al. | β | 2021 | β |
| Sodium Sensitivity, Sodium Resistance, and Incidence of Hypertension: A Longitudinal Follow-Up Study of Dietary Sodium Intervention. | He J et al. | β | 2021 | β |
| The Association between Gly460Trp-Polymorphism of Alpha-Adducin 1 Gene (<i>ADD1</i>) and Arterial Hypertension Development in Ukrainian Population. | Yermolenko S et al. | β | 2021 | β |
| The Effect of Alzheimer's Disease-Associated Genetic Variants on Longevity. | Tesi N et al. | β | 2021 | β |
| The effect of angiotensin-converting enzyme levels on COVID-19 susceptibility and severity: a Mendelian randomization study. | Butler-Laporte G et al. | β | 2021 | β |
| The genetic case for cardiorespiratory fitness as a clinical vital sign and the routine prescription of physical activity in healthcare. | Hanscombe KB et al. | β | 2021 | β |
| Translating genomic insights into cardiovascular medicine: Opportunities and challenges of CRISPR-Cas9. | Zhang Y et al. | β | 2021 | β |
| Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney. | Eales JM et al. | β | 2021 | β |
| White Matter Integrity and Nicotine Dependence: Evaluating Vertical and Horizontal Pleiotropy. | Ye Z et al. | β | 2021 | β |
| A 2020 Vision of Hypertension. | Cheung BMY et al. | β | 2020 | β |
| A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction. | Douglas G et al. | β | 2020 | β |
| Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies. | Ding J et al. | β | 2020 | β |
| Association of blood pressure with cognitive function at midlife: a Mendelian randomization study. | Sun D et al. | β | 2020 | β |
| Association of common genetic variants with brain microbleeds: A genome-wide association study. | Knol MJ et al. | β | 2020 | β |
| Association of Established Blood Pressure Loci With 10-Year Change in Blood Pressure and Their Ability to Predict Incident Hypertension. | Poveda A et al. | β | 2020 | β |
| Blood DNA methylation sites predict death risk in a longitudinal study of 12, 300 individuals. | Colicino E et al. | β | 2020 | β |
| Carotid Intima-Media Thickness: Novel Loci, Sex-Specific Effects, and Genetic Correlations With Obesity and Glucometabolic Traits in UK Biobank. | Strawbridge RJ et al. | β | 2020 | β |
| CNV Association of Diverse Clinical Phenotypes from eMERGE reveals novel disease biology underlying cardiovascular disease. | Glessner JT et al. | β | 2020 | β |
| Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval. | RamΓrez J et al. | β | 2020 | β |
| Conceptualization of Heterogeneity of Chronic Diseases and Atherosclerosis as a Pathway to Precision Medicine: Endophenotype, Endotype, and Residual Cardiovascular Risk. | Genkel VV et al. | β | 2020 | β |
| Current genetic engineering strategies for the production of antihypertensive ACEI peptides. | Gomes C et al. | β | 2020 | β |
| Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. | Surendran P et al. | β | 2020 | β |
| Effects of intron conversion in the human <i>CYP11B2</i> gene on its transcription and blood pressure regulation in transgenic mice. | Mopidevi B et al. | β | 2020 | β |
| Embracing study heterogeneity for finding genetic interactions in large-scale research consortia. | Liu Y et al. | β | 2020 | β |
| Enhancer Domains Predict Gene Pathogenicity and Inform Gene Discovery in Complex Disease. | Wang X et al. | β | 2020 | β |
| Functional variants in ADH1B and ALDH2 are non-additively associated with all-cause mortality in Japanese population. | Sakaue S et al. | β | 2020 | β |
| Genes Regulate Blood Pressure, but "Environments" Cause Hypertension. | Ji LD et al. | β | 2020 | β |
| Genetic background of high blood pressure is associated with reduced mortality in premature neonates. | GΓΆpel W et al. | β | 2020 | β |
| Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. | Hahn J et al. | β | 2020 | β |
| Genetic risk scores for coronary artery disease and its traditional risk factors: Their role in the progression of coronary artery calcification-Results of the Heinz Nixdorf Recall study. | Pechlivanis S et al. | β | 2020 | β |
| Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure. | Shah S et al. | β | 2020 | β |
| Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank. | Olafsdottir T et al. | β | 2020 | β |
| Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. | Coleman JRI et al. | β | 2020 | β |
| Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry. | de las Fuentes L et al. | β | 2020 | β |
| Genomic influences on self-reported childhood maltreatment. | Dalvie S et al. | β | 2020 | β |
| Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association. | Virani SS et al. | β | 2020 | β |
| Heritability and the Genetic Correlation of Heart Rate Variability and Blood Pressure in >29β000 Families: The Lifelines Cohort Study. | Tegegne BS et al. | β | 2020 | β |
| Hypertension and the roles of the 9p21.3 risk locus: Classic findings and new association data. | Gallo JE et al. | β | 2020 | β |
| Identification of Circulating Proteins Associated With Blood Pressure Using Mendelian Randomization. | ThΓ©riault S et al. | β | 2020 | β |
| Identifying cross-disease components of genetic risk across hospital data in the UK Biobank. | Cortes A et al. | β | 2020 | β |
| Inferring Gene-by-Environment Interactions with a Bayesian Whole-Genome Regression Model. | Kerin M et al. | β | 2020 | β |
| Influence of Genetic Variation in <i>PDE3A</i> on Endothelial Function and Stroke. | Traylor M et al. | β | 2020 | β |
| Mendelian Randomization Study: The Association Between Metabolic Pathways and Colorectal Cancer Risk. | Jung SY et al. | β | 2020 | β |
| Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. | Erzurumluoglu AM et al. | β | 2020 | β |
| Metabolites and Hypertension: Insights into Hypertension as a Metabolic Disorder: 2019 Harriet Dustan Award. | Chakraborty S et al. | β | 2020 | β |
| Molecular genetics of human hypertension. | Luft FC | β | 2020 | β |
| On the Clinical Pharmacology of Reactive Oxygen Species. | Casas AI et al. | β | 2020 | β |
| Ordered multinomial regression for genetic association analysis of ordinal phenotypes at Biobank scale. | German CA et al. | β | 2020 | β |
| Phosphodiesterase 3A and Arterial Hypertension. | Ercu M et al. | β | 2020 | β |
| Precision Medicine and Dilated Cardiomyopathy. | Li X et al. | β | 2020 | β |
| Rare genetic causes of complex kidney and urological diseases. | Groopman EE et al. | β | 2020 | β |
| Recent advances in the genetics of preterm birth. | Wadon M et al. | β | 2020 | β |
| Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort. | Khandaker GM et al. | β | 2020 | β |
| Sibling history is associated with heart failure after a first myocardial infarction. | Glinge C et al. | β | 2020 | β |
| The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly. | Pinese M et al. | β | 2020 | β |
| The support of genetic evidence for cardiovascular risk induced by antineoplastic drugs. | Cui H et al. | β | 2020 | β |
| The Use of Genomics to Drive Kidney Disease Drug Discovery and Development. | Reilly DF et al. | β | 2020 | β |
| Unraveling new factors associated with hypertension: the Mendelian randomization approach. | Grau-Perez M et al. | β | 2020 | β |
| Whole exome sequencing in patients with Williams-Beuren syndrome followed by disease modeling in mice points to four novel pathways that may modify stenosis risk. | Parrish PCR et al. | β | 2020 | β |
| Women's brain aging: Effects of sex-hormone exposure, pregnancies, and genetic risk for Alzheimer's disease. | de Lange AG et al. | β | 2020 | β |
| A genome-wide association and replication study of blood pressure in Ugandan early adolescents. | Lule SA et al. | β | 2019 | β |
| A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. | Sung YJ et al. | β | 2019 | β |
| A multimodal approach to cardiovascular risk stratification in patients with type 2 diabetes incorporating retinal, genomic and clinical features. | Fetit AE et al. | β | 2019 | β |
| Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links <i>Tmem63c</i> to kidney damage. | Schulz A et al. | β | 2019 | β |
| Association of School Residential PM<sub>2.5</sub> with Childhood High Blood Pressure: Results from an Observational Study in 6 Cities in China. | Wang X et al. | β | 2019 | β |
| Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits. | Kraja AT et al. | β | 2019 | β |
| Breast Cancer Risk and Insulin Resistance: Post Genome-Wide Gene-Environment Interaction Study Using a Random Survival Forest. | Jung SY et al. | β | 2019 | β |
| Camk2n1 Is a Negative Regulator of Blood Pressure, Left Ventricular Mass, Insulin Sensitivity, and Promotes Adiposity. | Alfazema N et al. | β | 2019 | β |
| CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation. | Esteghamat F et al. | β | 2019 | β |
| Detection of Putative Functional Single Nucleotide Polymorphisms in Blood Pressure Loci and Validation of Association Between Single Nucleotide Polymorphism in WBP1L and Hypertension in the Chinese Han Population. | Zhang H et al. | β | 2019 | β |
| Development and evaluation of a transfusion medicine genome wide genotyping array. | Guo Y et al. | β | 2019 | β |
| Dissecting features of epigenetic variants underlying cardiometabolic risk using full-resolution epigenome profiling in regulatory elements. | Allum F et al. | β | 2019 | β |
| Dissecting the association of autophagy-related genes with cardiovascular diseases and intermediate vascular traits: A population-based approach. | Portilla-Fernandez E et al. | β | 2019 | β |
| Effect of Previous Exposure to Malaria on Blood Pressure in Kilifi, Kenya: A Mendelian Randomization Study. | Etyang AO et al. | β | 2019 | β |
| Effect of Systolic Blood Pressure on Left Ventricular Structure and Function: A Mendelian Randomization Study. | Hendriks T et al. | β | 2019 | β |
| Gene and environmental interactions according to the components of lifestyle modifications in hypertension guidelines. | Kokubo Y et al. | β | 2019 | β |
| Generality of genomic findings on blood pressure traits and its usefulness in precision medicine in diverse populations: A systematic review. | Kolifarhood G et al. | β | 2019 | β |
| Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. | Chauhan G et al. | β | 2019 | β |
| Genetic Association of Finger Photoplethysmography-Derived Arterial Stiffness Index With Blood Pressure and Coronary Artery Disease. | Zekavat SM et al. | β | 2019 | β |
| Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent. | HΓΌbel C et al. | β | 2019 | β |
| Genetics of Blood Pressure Regulation: Possible Paths in the Labyrinth. | Foco L et al. | β | 2019 | β |
| Genetics of Human Primary Hypertension: Focus on Hormonal Mechanisms. | Manosroi W et al. | β | 2019 | β |
| Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals. | Iniesta R et al. | β | 2019 | β |
| Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women. | Lawrenson K et al. | β | 2019 | β |
| Genome-Wide Association Studies of Hypertension and Several Other Cardiovascular Diseases. | Wang Y et al. | β | 2019 | β |
| Genome-wide association study identifies loci for arterial stiffness index in 127,121 UK Biobank participants. | Fung K et al. | β | 2019 | β |
| Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group. | Irvin MR et al. | β | 2019 | β |
| Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects. | Rask-Andersen M et al. | β | 2019 | β |
| Genome-wide association study of medication-use and associated disease in the UK Biobank. | Wu Y et al. | β | 2019 | β |
| Genome-wide linkage analysis of carotid artery traits in exceptionally long-lived families. | Kuipers AL et al. | β | 2019 | β |
| Genome-wide meta-analysis of SNP and antihypertensive medication interactions on left ventricular traits in African Americans. | Do AN et al. | β | 2019 | β |
| Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke. | Abraham G et al. | β | 2019 | β |
| Genomics of body fat percentage may contribute to sex bias in anorexia nervosa. | HΓΌbel C et al. | β | 2019 | β |
| Haploinsufficiency of ARHGAP42 is associated with hypertension. | Fjorder AS et al. | β | 2019 | β |
| Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association. | Benjamin EJ et al. | β | 2019 | β |
| Improved detection of common variants in coronary artery disease and blood pressure using a pleiotropy cFDR method. | Mao XJ et al. | β | 2019 | β |
| Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene. | Lalonde S et al. | β | 2019 | β |
| Integrative Genomics Analysis Unravels Tissue-Specific Pathways, Networks, and Key Regulators of Blood Pressure Regulation. | Zhao Y et al. | β | 2019 | β |
| Leveraging linkage evidence to identify low-frequency and rare variants on 16p13 associated with blood pressure using TOPMed whole genome sequencing data. | He KY et al. | β | 2019 | β |
| Linking glycemic dysregulation in diabetes to symptoms, comorbidities, and genetics through EHR data mining. | Kirk IK et al. | β | 2019 | β |
| Long-Term Cardiovascular Risk inΒ WomenΒ With Hypertension DuringΒ Pregnancy. | Honigberg MC et al. | β | 2019 | β |
| Long-Term Exposure to Elevated Systolic Blood Pressure in Predicting Incident Cardiovascular Disease: Evidence From Large-Scale Routine Electronic Health Records. | Ayala Solares JR et al. | β | 2019 | β |
| Loss of reticulocalbin 2 lowers blood pressure and restrains ANG II-induced hypertension in vivo. | Li J et al. | β | 2019 | β |
| Natural selection and local adaptation of blood pressure regulation and their perspectives on precision medicine in hypertension. | Hoh BP et al. | β | 2019 | β |
| Neuroimmune crosstalk in the pathophysiology of hypertension. | Calvillo L et al. | β | 2019 | β |
| Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated. | Cabrera CP et al. | β | 2019 | β |
| Pharmacogenomics And Hypertension: Current Insights. | Oliveira-Paula GH et al. | β | 2019 | β |
| Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery. | Aragam KG et al. | β | 2019 | β |
| Precision Medicine. | Loscalzo J | β | 2019 | β |
| Precision Medicine in Non Communicable Diseases. | Hasanzad M et al. | β | 2019 | β |
| Precision Medicine in the Management of Dilated Cardiomyopathy: JACC State-of-the-Art Review. | Fatkin D et al. | β | 2019 | β |
| Pre-emptive medicine for hypertension and its prospects. | Itoh H et al. | β | 2019 | β |
| Sequence variants with large effects on cardiac electrophysiology and disease. | Norland K et al. | β | 2019 | β |
| simGWAS: a fast method for simulation of large scale case-control GWAS summary statistics. | Fortune MD et al. | β | 2019 | β |
| SNPs rs10224002 in PRKAG2 may disturb gene expression and consequently affect hypertension. | Mo X et al. | β | 2019 | β |
| The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019). | Umemura S et al. | β | 2019 | β |
| The Older Finnish Twin Cohort - 45 Years of Follow-up. | Kaprio J et al. | β | 2019 | β |
| The role of DNA methylation and histone modifications in blood pressure: a systematic review. | Gonzalez-Jaramillo V et al. | β | 2019 | β |
| The SLC transporter in nutrient and metabolic sensing, regulation, and drug development. | Zhang Y et al. | β | 2019 | β |
| Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. | Giri A et al. | β | 2019 | β |
| Transgenic overexpression of glutathione S-transferase ΞΌ-type 1 reduces hypertension and oxidative stress in the stroke-prone spontaneously hypertensive rat. | Olson E et al. | β | 2019 | β |
| Type 2 Diabetes and Hypertension. | Sun D et al. | β | 2019 | β |
| Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study. | Carter AR et al. | β | 2019 | β |
| Validation of Genome-Wide Polygenic Risk Scores for Coronary Artery Disease in French Canadians. | WΓΌnnemann F et al. | β | 2019 | β |
| 2018 ESC/ESH Guidelines for the management of arterial hypertension. | Williams B et al. | β | 2018 | β |
| 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. | Williams B et al. | β | 2018 | β |
| Adjustment for covariates using summary statistics of genome-wide association studies. | Wang T et al. | β | 2018 | β |
| Admixture mapping and fine-mapping of birth weight loci in the Black Women's Health Study. | Ochs-Balcom HM et al. | β | 2018 | β |
| Advances in the Genetics of Hypertension: The Effect of Rare Variants. | Russo A et al. | β | 2018 | β |
| A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. | Sung YJ et al. | β | 2018 | β |
| Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease. | Emdin CA et al. | β | 2018 | β |
| An Overview of Metabolic Phenotyping in Blood Pressure Research. | Tzoulaki I et al. | β | 2018 | β |
| A randomized controlled crossover trial evaluating differential responses to antihypertensive drugs (used as mono- or dual therapy) on the basis of ethnicity: The comparIsoN oF Optimal Hypertension RegiMens; part of the Ancestry Informative Markers in HYpertension program-AIM-HY INFORM trial. | Mukhtar O et al. | β | 2018 | β |
| Associations of Combined Genetic and Lifestyle Risks With Incident Cardiovascular Disease and Diabetes in the UK Biobank Study. | Said MA et al. | β | 2018 | β |
| Associations of NADPH oxidase-related genes with blood pressure changes and incident hypertension: The GenSalt Study. | Li H et al. | β | 2018 | β |
| Bevacizumab-induced hypertension: Clinical presentation and molecular understanding. | Li M et al. | β | 2018 | β |
| Brief Overview of a Decade of Genome-Wide Association Studies on Primary Hypertension. | Azam AB et al. | β | 2018 | β |
| Causal Pathways from Blood Pressure to Larger Qrs Amplitudes a Mendelian Randomization Study. | Van Der Ende MY et al. | β | 2018 | β |
| Challenges in Sex- and Gender-Centered Prevention and Management of Cardiovascular Disease: Implications of Genetic, Metabolic, and Environmental Paths. | Kouvari M et al. | β | 2018 | β |
| Chrm3 Gene and M3 Muscarinic Receptors Contribute to Salt-Sensitive Hypertension. | Cowley AW | β | 2018 | β |
| Conditional and interaction gene-set analysis reveals novel functional pathways for blood pressure. | de Leeuw CA et al. | β | 2018 | β |
| Contributions of rare coding variants in hypotension syndrome genes to population blood pressure variation. | Nandakumar P et al. | β | 2018 | β |
| Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. | Verbanck M et al. | β | 2018 | β |
| Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. | Evangelou E et al. | β | 2018 | β |
| Genetic and Environmental Effects on Gene Expression Signatures of Blood Pressure: A Transcriptome-Wide Twin Study. | Huang Y et al. | β | 2018 | β |
| Genetic Predisposition to High Blood Pressure and Lifestyle Factors: Associations With Midlife Blood Pressure Levels and Cardiovascular Events. | Pazoki R et al. | β | 2018 | β |
| Genetic Risk Score Is Associated with Vertical Cup-to-Disc Ratio and Improves Prediction of Primary Open-Angle Glaucoma in Latinos. | Nannini DR et al. | β | 2018 | β |
| Genetics of CVD in 2017: Expanding the spectrum of CVD genetics. | Schunkert H | β | 2018 | β |
| Genetics of metabolic syndrome: potential clues from wild-derived inbred mouse strains. | Karunakaran S et al. | β | 2018 | β |
| Gene Variation of Endoplasmic Reticulum Aminopeptidases 1 and 2, and Risk of Blood Pressure Progression and Incident Hypertension among 17,255 Initially Healthy Women. | Zee RYL et al. | β | 2018 | β |
| Genome-wide association study of homocysteine in African Americans from the Jackson Heart Study, the Multi-Ethnic Study of Atherosclerosis, and the Coronary Artery Risk in Young Adults study. | Raffield LM et al. | β | 2018 | β |
| Genome-wide association study of offspring birth weight in 86β577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. | Beaumont RN et al. | β | 2018 | β |
| Genotype imputation performance of three reference panels using African ancestry individuals. | Vergara C et al. | β | 2018 | β |
| GWAS Reveal Targets in Vessel Wall Pathways to Treat Coronary Artery Disease. | Turner AW et al. | β | 2018 | β |
| Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association. | Benjamin EJ et al. | β | 2018 | β |
| Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography. | LukΓ‘cs Krogager M et al. | β | 2018 | β |
| Hypertension genomics and cardiovascular prevention. | Ng FL et al. | β | 2018 | β |
| Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease. | Yamada Y et al. | β | 2018 | β |
| Identification of novel hyper-Β or hypomethylated CpG sites and genes associated with atherosclerotic plaque using an epigenome-wide association study. | Yamada Y et al. | β | 2018 | β |
| Integrative Bioinformatics Approaches for Identification of Drug Targets in Hypertension. | Hemerich D et al. | β | 2018 | β |
| Interethnic analyses of blood pressure loci in populations of East Asian and European descent. | Takeuchi F et al. | β | 2018 | β |
| Iron Status and Risk of Stroke. | Gill D et al. | β | 2018 | β |
| Is There a Role for Genes in Exercise-Induced Atrial Cardiomyopathy? | Fatkin D et al. | β | 2018 | β |
| MicroRNA-214-3p in the Kidney Contributes to the Development of Hypertension. | Liu Y et al. | β | 2018 | β |
| Missing Heritability of Hypertension and Our Microbiome. | Marques FZ | β | 2018 | β |
| Nitric oxide signalling in cardiovascular health and disease. | Farah C et al. | β | 2018 | β |
| Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. | Feitosa MF et al. | β | 2018 | β |
| Pharmacogenomic studies of hypertension: paving the way for personalized antihypertensive treatment. | Eadon MT et al. | β | 2018 | β |
| Pleiotropic mapping and annotation selection in genome-wide association studies with penalized Gaussian mixture models. | Zeng P et al. | β | 2018 | β |
| Polygenic Contribution in Individuals With Early-Onset Coronary Artery Disease. | ThΓ©riault S et al. | β | 2018 | β |
| Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. | Turcot V et al. | β | 2018 | β |
| Scientific Contributions of Population-Based Studies to Cardiovascular Epidemiology in the GWAS Era. | Lieb W et al. | β | 2018 | β |
| Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease. | Park J et al. | β | 2018 | β |
| The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle. | Ren M et al. | β | 2018 | β |
| The norepinephrine transporter deserves more attention. | Jordan J et al. | β | 2018 | β |
| Varicose Veins Reach New Heights. | Wells QS | β | 2018 | β |
| Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II-mediated blood pressure control. | Patel J et al. | β | 2018 | β |
| A comparison of methods for inferring causal relationships between genotype and phenotype using additional biological measurements. | Ainsworth HF et al. | β | 2017 | β |
| An Exploration of Gene-Gene Interactions and Their Effects on Hypertension. | Meng Y et al. | β | 2017 | β |
| A Review of the Genetics of Hypertension with a Focus on Gene-Environment Interactions. | Waken RJ et al. | β | 2017 | β |
| Assessing genetic risk of hypertension at an early age: future research directions. | Wang X et al. | β | 2017 | β |
| Cross-Phenotype Association Analysis Using Summary Statistics from GWAS. | Li X et al. | β | 2017 | β |
| DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation. | Richard MA et al. | β | 2017 | β |
| Epigenetics of Atherosclerosis: Emerging Mechanisms and Methods. | Khyzha N et al. | β | 2017 | β |
| Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion. | Ndiaye FK et al. | β | 2017 | β |
| Gene-by-Psychosocial Factor Interactions Influence Diastolic Blood Pressure in European and African Ancestry Populations: Meta-Analysis of Four Cohort Studies. | Smith JA et al. | β | 2017 | β |
| Genetic mechanisms of human hypertension and their implications for blood pressure physiology. | Seidel E et al. | β | 2017 | β |
| Genetics of hypertension: an assessment of progress in the spontaneously hypertensive rat. | Doris PA | β | 2017 | β |
| Genome-Wide Association Study of Blood Pressure Traits by Hispanic/Latino Background: the Hispanic Community Health Study/Study of Latinos. | Sofer T et al. | β | 2017 | β |
| Genomics of hypertension. | Padmanabhan S et al. | β | 2017 | β |
| Hypertension: From GWAS to functional genomics-based precision medicine. | Mattson DL et al. | β | 2017 | β |
| In Retrospect: A decade of shared genomic associations. | Manolio TA | β | 2017 | β |
| New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475β000 Individuals. | Kraja AT et al. | β | 2017 | β |
| Next Steps for Gene Identification in Primary Hypertension Genomics. | Ehret G | β | 2017 | β |
| Non-parametric genetic prediction of complex traits with latent Dirichlet process regression models. | Zeng P et al. | β | 2017 | β |
| Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. | Wain LV et al. | β | 2017 | β |
| Physiological and Pathological Roles in Human Adrenal of the Glomeruli-Defining Matrix Protein NPNT (Nephronectin). | Teo AE et al. | β | 2017 | β |
| Renal function and its association with blood pressure in Middle Eastern immigrants and native Swedes. | Nilsson C et al. | β | 2017 | β |
| Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations. | Liang J et al. | β | 2017 | β |
| Towards Precision Medicine for Hypertension: A Review of Genomic, Epigenomic, and Microbiomic Effects on Blood Pressure in Experimental Rat Models and Humans. | Padmanabhan S et al. | β | 2017 | β |
| Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure. | Zeller T et al. | β | 2017 | β |
| Understanding the role of genetics in hypertension. | Patel RS et al. | β | 2017 | β |