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Chunk #2 — Results — Genetic variants at novel and previously unvalidated loci

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Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
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After conditional analysis on the sentinel SNV we identify an independent validated secondary SNV at five of the 107 loci (Supplementary Table 8a; Supplementary Table 9). Compared with previously reported SNVs at the time of analysis, the contribution of our validated loci increases the percentage trait variance explained by ˜1%, e.g. to 3.56% for SBP.