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Chunk #1 — Results — Genetic variants at novel and previously unvalidated loci

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Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
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Of the 107 validated loci, 24 are reported for association with SBP as the primary trait (most significant from combined meta-analysis), 41 for DBP and 42 for PP, although many loci are associated with more than one BP trait (Supplementary Fig. 4). For example, in the combined meta-analysis, 24 validated loci are associated with both SBP and DBP, 11 with SBP and PP, one locus with DBP and PP and four loci (NADK-CPSF3L, GTF2B, METTL21A-AC079767.3 and PAX2) with all three traits at genome-wide significance (Fig. 2).