Of the 240 loci taken forward to replication, we validate 107 loci at P < 5x10-8, of which 102 derive from the GWAS analysis replicated and meta-analyzed in a total of 330,956 individuals (Tables 1-3; Supplementary Fig. 2a-c; Supplementary Fig. 3a), and a further five from the exome analysis in a total of 422,604 individuals (Tables 1-3 and Supplementary Fig. 3b; Supplementary Tables 4, 5 and 6). Thirty-two of these validated loci are novel findings. Since the time of analysis, the remaining 75 loci have also been reported in another study15, although at least 53 of these were previously unvalidated (Tables 1-3), hence we now validate these loci for the first time. We therefore present results here for all 107 validated loci in our study. Most SNVs also show association with hypertension in the UK Biobank data, for example 93 of the 107 validated sentinel SNVs are nominally significant (P < 0.01) (Supplementary Table 7).
