We report signals at known hypertension drug targets, including the angiotensin converting enzyme (ACE) locus (rs4308, P = 6.8 x 10-14, ACE-inhibitors), CACNA2D2 (rs743757, P = 2.4 x 10-10, calcium channel blockers), MME (rs143112823 in the RP11-439C8.2 locus, P = 1.4 x 10-14, omapatrilat), ADRA2B (rs2579519 in the GPAT2-FAHD2CP locus, P = 4.8 x 10-12, beta blockers), SLC14A2 (rs7236548, P = 2.0 x 10-18, nifedipine), and phosphodiesterase 5A (PDE5A; rs66887589, P = 3.4 x 10-15, sildenafil).
