We annotate the 107 validated loci to 212 genes (based on LD r2 ≥0.8) and seek putative function from in silico analyses and gene expression experiments. Candidate genes with the strongest supporting evidence are indicated in the last column of Supplementary Table 4 with an indication of the supporting data source. All genome-wide significant variants in LD (r2>0.8) with the variants reported here, ranked by supporting evidence, are annotated in Supplementary Table 15. Of the 107 validated sentinel SNVs three are Indels; all other variants are single nucleotide polymorphisms (SNPs). We identify non-synonymous SNVs at 13 of the 107 validated loci (Supplementary Table 16), three of which are predicted to be damaging (ANNOVAR) in TFAP2D (rs78648104), NOX4 (rs56061986) and CCDC141 (rs17362588, reported to be associated with heart rate20) (Supplementary Fig. 5a). Beyond the coding regions we identify 29 SNVs in 3’UTRs which are predicted to significantly weaken or cause loss of miRNA regulation by altering the recognition motif in seven genes, and strengthen or create target sites for miRNA binding in 13 genes (based on miRNASNP db, Supplementary Table 16).
