We also examine findings for low-frequency and rare gene mutations previously reported to be associated with monogenic hypertension disorders19 and included on the UK Biobank gene array. Despite lack of power overall, the variant with the lowest P-value (rs387907156; KLH3; MAF=0.02%) has a seemingly large effect on BP: 8.2 mm Hg (SE=4.1, P = 0.046) per allele for SBP; 5.6 mm Hg (SE=2.6, P = 0.048) for PP (Supplementary Table 14).
