To identify long range target genes of non-coding variants, we use chromatin interaction (Hi-C) data from HUVEC, as enhancers and silencers often form chromatin loops with their target promoter. In most loci the strongest promoter interaction involves a gene in high LD with the SNV, but for 21 loci we find a distal potential target gene (Supplementary Table 16). Pathway analysis of the distal genes shows greatest enrichment in regulators of cardiac hypertrophy.
