Additionally, Ingenuity pathway analysis and upstream transcriptional analysis show enrichment of canonical pathways implicated in cardiovascular disease, including those targeted by antihypertensive drugs, such as the alpha-adrenergic, CXCR4, endothelin signalling and angiotensin receptor pathways (Supplementary Table 19). In keeping with vascular mediation of genetic influence we identify diphenyleneiodonium, an inhibitor of flavin-containing oxidases, including NAD(P)H oxidase (NOX), which is reported to reverse endothelial dysfunction (and hypertension) in a rat model21.
