Chunk #60 — 6.0 How Do Electrophysiological Endophenotypes Compare with Other Quantitative Traits? — 6.3 Summary: Endophenotype genetic effect sizes and architecture resemble that seen for other complex traits
that endophenotypes are massively polygenic, with many thousands of variants each contributing very small effects. Although our results could be unique to our set of endophenotypes and sample, the data available for other heritable quantitative traits, such as those listed in Figure 1, provide little reason to believe this to be the case. We are persuaded that these results in aggregate shift the burden of proof to those who would argue otherwise. Endophenotypes may ultimately confer some advantages in finding genes related to psychological outcomes, but those advantages are not likely to be great and are outweighed by the high relative cost of an electrophysiological lab session versus, for example, a questionnaire or interview.
