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Chunk #17 — Methods — eQTL Selection

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Mapping of gene expression reveals CYP27A1 as a susceptibility gene for sporadic ALS.
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Only these SNP-transcript pairs were used for follow-up in the replication data. Patient characteristics for the expression replication dataset are presented in Table S1. SNP genotypes were correlated to gene expression levels following a similar statistical analysis as used for our discovery set. Again, a 5% FDR significance threshold was applied.