such that these effects are not wholly attributable to alcohol. Therefore, subjective response is captured in different ways (i.e., drink estimates vs. ratings of effects experienced) for the retrospective measures and the alcohol challenge, which could decrease the likelihood that effects will generalize across both modalities. In addition, the retrospective measures require an individual to reference an entire episode of drinking, compared to the repeated momentary estimations provided over the course of a drinking episode during the alcohol challenge and the subsequent conclusion of subjective response assessments before an individual’s BrAC returns to zero (upon reaching 0.02%). Finally, important differences in components such as the rapidity of intoxication and peak BAC achieved are likely to impact a person’s subjective response to alcohol. As such, these findings warrant further investigation of this genomic region and its relation to alcohol use phenotypes.
