It is worth noting, however, that the mixed relations of rs1799971 with measures of subjective response to alcohol in past studies may also extend to rs3778150. The associations of rs3778150 with the sedative effects of alcohol based on retrospective self-report measures (i.e., SRE, ASQ) in the current study did not generalize to the alcohol challenge; rs3778150 was instead related to lower levels of maximum alcohol-related stimulation. Numerous factors could account for these inconsistent associations of rs3778150 with different facets of subjective response. The retrospective self-report measures instruct individuals to estimate the number of drinks needed to experience specific effects related to stimulation or sedation for different time periods. In contrast, alcohol sensitivity is assessed during the alcohol challenge by having participants rate the extent to which they are experiencing different states that tap stimulation or sedation, but items are worded such that these effects are not wholly attributable to alcohol. Therefore, subjective response is captured in different ways (i.e., drink estimates vs. ratings of effects experienced) for the retrospective measures and the alcohol challenge, which could decrease the likelihood that
