In a Brazilian sample of alcoholic men (Bau, Almeida, & Hutz, 2000), there was significant GxE (explaining 6.6% of the variance in physiologic dependence symptoms), such that SLEs were associated with a greater number of physiological AD symptoms (but not other AD symptoms or antisocial personality symptoms) among those with the Taq A1 allele compared to those without an A1 allele. Lastly, in a sample of adult males of Mayan descent in Honduras, Madrid, MacMurray, Lee, Anderson, and Comings (2001) found an interaction between Taq1 genotype and level of occupational and economic stress on AA symptoms. Carriers of the A1 allele had a greater number of AA symptoms when exposed to increasing amounts of life stress (low stress = 0.6 – 2.5, moderate stress = 1.8 – 2.2, high stress = 4.8 –7.0). There was little influence of level of stress on AA symptoms among A2 allele homozygotes (symptom range 2.9–3.7).
