updated the regulatory build three times, each time adding more data (35,36) and a more sophisticated analysis of the chromatin conformation and modification data. The build now consists of approximately 175 000 genomic regions defined from data collected from several cell types, including CD4 cells which make up the majority of the supporting data. Approximately 40 different histone modifications are now included and more than 2700 combinations of these factors form patterns associated with protein coding genes or their promoters allowing over 23 000 of the regulatory features to be classified as gene- or promoter-associated.
