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Chunk #19 — Alcohol dehydrogenases — ADH1B*2

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Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical Review.
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A meta-analysis provided strong evidence for association of ADH1B*2 with AD (p=1.2×10−31) and symptom count (p=1.9×10−23) (Gelernter et al., 2014). The latest and largest meta-analysis to date also provides strong evidence for the association of ADH1B*2 with AD in individuals of European ancestry, p= 9.8×10−13 (Walters et al., 2018).