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Chunk #79 — Results — Detecting recombination events — Using detected recombinations for association scans of hotspot usage

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A general approach for haplotype phasing across the full spectrum of relatedness.
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Figure S34 (left) shows the signal of association in the PRDM9 region for a meta analysis of all the European cohorts (GPC excluded). When only the 618 informative parents were used (top) we found a minimum P-value of at SNP rs2162866. The addition of 466 individuals lead to a modest increase in signal () at the same SNP. Figure S34 (right) plots the when all individuals are used against the when only informative individuals are used, demonstrating a consistent increase in signal in the region. This suggests that our method is indeed detecting true recombination events.