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Chunk #78 — Results — Detecting recombination events — Uninformative duos

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A general approach for haplotype phasing across the full spectrum of relatedness.
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Figure 7 (left) shows ROC curves for detecting recombination events applied to our simulated uninformative meioses. We found that recombination events could be detected with low false discovery rates, but the power of the method to detect recombination events is clearly limited by the demography of the sample. When closely related individuals were not removed we see that 53.51% of events could be detected with a false discovery rate of 5%, but when closely related individuals were filtered we could only detect 34.10% of events with 5% false discovery rate (posterior probability threshold of 0.7). Importantly, the posterior probabilities of a recombination event appear roughly calibrated (Figure 7 right) so by setting a high probability threshold, researchers can be confident they are detecting true events with our method.