In the LGC meta-analysis (Table 3), Problems PGSs were significantly associated with a higher slope value for CON (meta β=0.470, p=4.20E-06), meaning that higher genetic risk predicted an accelerated trajectory of increasing drinking frequency over time. There was a general trend that higher PGSs for the genetic dimensions examined were associated with higher intercept and slope values and lower quadratic factor values (i.e., less leveling off of drinking behaviors over time) for both CON and HED, and some were significant in individual cohorts, but these trends were not statistically significant in the combined meta-analysis. Substantial heterogeneity was observed in the estimates across samples, with I2 values of up to 92%. Again, an exception was seen for Problems PGSs predicting CON trajectories, which had not only the strongest effects but also the most consistent ones (I2=0%−2%).
