Chunk #15 — Results — Inference of sample purity and ploidy in cancer-derived DNA

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Absolute quantification of somatic DNA alterations in human cancer.

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The ABSOLUTE algorithm examines possible mappings from relative to integer copy numbers by jointly optimizing the two parameters α and τ (Supplementary Fig. 1c-d,h-i; Online Methods Eq. 5). In many cases, several such mappings are possible, corresponding to multiple optima.