Chunk #5 — Introduction

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Genetic variation in healthy oldest-old.

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have been identified in animal studies and include sirtuins (SIRT1 (GeneID: 23411), SIRT3 (GeneID: 23410)), uncoupling proteins (UCP2 (GeneID: 7351), UCP3 (GeneID: 7352)), PPARG (GeneID: 5468) and PPARGC1A (GeneID: 10891). Additional candidate gene categories chosen, included autophagy (BECN1 (GeneID: 8678), FRAP1 (GeneID: 2475)), tumor suppression (TP53 (GeneID: 7157), CDKN2A (GeneID: 1029), ING1 (GeneID: 601566)), DNA methylation (TRDMT1 (GeneID: 1787), DNMT3A (GeneID: 1788), DNMT3B (GeneID: 1789)), stem cell activation (NOTCH1 (GeneID: 4851), DLL1 (GeneID: 28514)), and Progeria syndromes (LMNA (GeneID: 4000), ZMPSTE24 (GeneID: 10269), KL (GeneID: 9365)). References for all candidate genes are provided in Table 1 .