When testing predictions from the 2013 genetic association data, it was important that MeSH headings mapped to Pharmaprojects indications be consistent with the original analysis by Nelson et al. in order to correctly identify common pairs between datasets for which progression can be tested and to ensure that our New Pipeline test set contained truly novel pairs. Nelson et al. provided mappings for many Pharmaprojects indications in a supplementary dataset. Terms without provided mappings were mapped to maximize the number of Nelson et al. gene target-indication pairs also present in our dataset, subject to the mapping being biologically justifiable. Standardized mapping increased the percent of Nelson et al gene target-indication pairs present in our dataset from 88% (using our independently mapped terms) to 98%.
