Pharmaprojects indications and GWAS Catalog and OMIM traits were mapped to MeSH headings to link traits and indications by a common vocabulary. We mapped as many terms as possible automatically by string matching to MeSH terms and their synonyms, and the remainder were manually assigned to the most specific MeSH heading encompassing the term. The MeSH vocabulary consists of MeSH headings, which are organized in a hierarchy, and supplementary concepts, which are not. We did not map to MeSH supplementary concepts as the lack of structure means we cannot compute similarities between these concepts and other terms. However, each supplementary concept is assigned one or more mapped headings, and so terms matching a supplementary concept were assigned to the mapped heading. This set of MeSH term mappings was used in the full replication with new genetic data sources.
