In a British cohort (the Whitehall II study), a panel of 20 genotypes associated with type 2 diabetes performed less well than the Cambridge and Framingham offspring type 2 diabetes risk scores in discriminating incident cases of type 2 diabetes. Adding the genetic panel to the phenotype based risk models did not improve discrimination and produced only minimal improvement in accuracy of risk estimation assessed by recalibration and, at best, a minor net reclassification improvement.
