Included in our replication data were 3 SNPs near published POAG risk genes which showed strong evidence for association in our discovery data. SNPs in SRBD1 and MTAP (near CDKN2B) both showed strongest evidence for the HTG group, and a SNP in CDKN2B which showed strongest evidence in the NTG group. However, these SNPs were not significant in our replication sample (Appendix 4). Table 4 gives a summary of the evidence for published POAG genes, with SRBD1, CDKN2B, and TMCO1 giving the most convincing evidence in our larger discovery sample. The best of several significant SNPs within SRBD1 is rs11884064 (p=6.7×10−5), though nearby rs1657855 is marginally more significant (p=2.69×10−5).
