In vitro studies have shown that cannabinoids can inhibit a number of hepatic enzymes that metabolize common drugs, including CYP2D6 (95), CYP2C19 (96), CYP2C9 (97), and CYP3A4 (98). Other evidence in humans suggests that marijuana may also interfere with the drug concentrations of warfarin (99) and antiretroviral therapies (100). Further research is needed to explore how components of marijuana might interact with other medications in a clinical setting.
