Power estimates for this study were calculated using QUANTO 1.2.4 (http://hydra.usc.edu/gxe) for the dichotomous AD outcome (Table 1) and the continuous traits (Table 2) using a two-sided t-test with a significance level of 0.05 and a range of MAF from 0.05 to 0.4. We assumed an additive mode of inheritance. Effect sizes are listed as OR from 1.1 to 1.5 for AD and variation in the traits from 1 to 5% for continuous outcomes. The power for the dichotomous outcome was based on a lifetime population risk for AD of 12.5% (Hasin et al., 2007).
