Chunk #14 — 3. Results — 3.1. Evaluating the interaction between the 5-HTTLPR short allele and childhood maltreatment in predicting persistent adult depression

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Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results.

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Persistent depression was operationally defined as meeting diagnostic criteria for major depression on two or more of the four assessment occasions in adulthood. In the Dunedin cohort, 138 individuals (16.3%) fulfilled criteria for persistent depression. In the E-Risk cohort, 117 (12.6%) fulfilled criteria for persistent depression. Fig. 1 shows the association between childhood maltreatment and persistent depression by 5-HTTLPR genotype in Dunedin (Panel A) and E-risk (Panel B).